1vk0

X-ray Structure of Gene Product from Arabidopsis Thaliana At5g06450X-ray Structure of Gene Product from Arabidopsis Thaliana At5g06450

Structural highlights

1vk0 is a 6 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RICE2_ARATH 3'-to-5' exoribonuclease (RNase) specifically targeting single-stranded RNAs (PubMed:28463111). Triggers miRNA accumulation in RNA-induced silencing complex (RISC), composed of miRNAs and AGO proteins, by degrading uridylated cleavage fragments (PubMed:28463111). Required during plant growth and development (By similarity).[UniProtKB:Q9SF21]^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Zhang Z, Hu F, Sung MW, Shu C, Castillo-Gonzalez C, Koiwa H, Tang G, Dickman M, Li P, Zhang X. RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana. Elife. 2017 May 2;6. pii: e24466. doi: 10.7554/eLife.24466. PMID:28463111 doi:http://dx.doi.org/10.7554/eLife.24466

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OCA

[1] Zhang Z, Hu F, Sung MW, Shu C, Castillo-Gonzalez C, Koiwa H, Tang G, Dickman M, Li P, Zhang X. RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana. Elife. 2017 May 2;6. pii: e24466. doi: 10.7554/eLife.24466. PMID:28463111 doi:http://dx.doi.org/10.7554/eLife.24466

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