Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
Structural highlights
1v5s is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
MARK3_MOUSE Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.