1ugv

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

Structural highlights

1ugv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

RHG26_HUMAN Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.

Function

RHG26_HUMAN GTPase-activating protein for RHOA and CDC42.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA