1tt9

Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamerStructure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer

Structural highlights

1tt9 is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.42Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FTCD_RAT Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).^[1] Binds and promotes bundling of vimentin filaments originating from the Golgi.^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Gao YS, Vrielink A, MacKenzie R, Sztul E. A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein. Eur J Cell Biol. 2002 Jul;81(7):391-401. PMID:12160147 doi:10.1078/0171-9335-00260
↑ Gao YS, Vrielink A, MacKenzie R, Sztul E. A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein. Eur J Cell Biol. 2002 Jul;81(7):391-401. PMID:12160147 doi:10.1078/0171-9335-00260

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OCA

[1] Gao YS, Vrielink A, MacKenzie R, Sztul E. A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein. Eur J Cell Biol. 2002 Jul;81(7):391-401. PMID:12160147 doi:10.1078/0171-9335-00260

[2] Gao YS, Vrielink A, MacKenzie R, Sztul E. A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein. Eur J Cell Biol. 2002 Jul;81(7):391-401. PMID:12160147 doi:10.1078/0171-9335-00260

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