Crystal structure of the viral Zalpha domain bound to left-handed Z-DNACrystal structure of the viral Zalpha domain bound to left-handed Z-DNA
Structural highlights
1sfu is a 4 chain structure with sequence from Yaba-like disease virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
E3_YLDV RNA-binding protein that plays a role in the inhibition of multiple cellular antiviral responses activated by double-stranded RNA (dsRNA), such as inhibition of PKR activation, necroptosis, and IFN-mediated antiviral activities (By similarity). Recognizes and binds Z-RNA structures via its Z-binding domain and dsRNA via its DRBM domain: RNA-binding activity is required to escape host ZBP1-dependent necroptosis (By similarity). Mechanistically, the Z-binding domain binds Z-RNAs that are produced during Yaba-like disease virus infection, thereby competing with Z-RNA detection by host ZBP1, suppressing ZBP1-dependent necroptosis (By similarity).[UniProtKB:P21605]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
