Crystal structure of the Middle Operon Regulator protein of Bacteriophage MuCrystal structure of the Middle Operon Regulator protein of Bacteriophage Mu
Structural highlights
1rr7 is a 1 chain structure with sequence from Escherichia virus Mu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
MOR_BPMU Activator of the Pm promoter, which controls middle genes expression. Activation of Pm allows expression of protein C necessary for late gene expression. In addition to Mor binding, activation of Pm might require the interaction of Mor with the C-terminus of host RNAP subunits RpoA and RpoH.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Giusti M, Di Lallo G, Ghelardini P, Paolozzi L. The bacteriophage Mu gem gene: a positive regulator of the C operon required for normal levels of late transcription. Virology. 1990 Dec;179(2):694-700. PMID:2173258 doi:10.1016/0042-6822(90)90136-f
↑Artsimovitch I, Kahmeyer-Gabbe M, Howe MM. Distortion in the spacer region of Pm during activation of middle transcription of phage Mu. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9408-13. PMID:8790343 doi:10.1073/pnas.93.18.9408
