1ps6

Crystal structure of E.coli PdxACrystal structure of E.coli PdxA

Structural highlights

1ps6 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.25Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDXA_ECOLI Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).[REFERENCE:5]^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Banks J, Cane DE. Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1633-6. PMID:15026039 doi:http://dx.doi.org/10.1016/j.bmcl.2004.01.065

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OCA

[1] Banks J, Cane DE. Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1633-6. PMID:15026039 doi:http://dx.doi.org/10.1016/j.bmcl.2004.01.065

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