1kol

Crystal structure of formaldehyde dehydrogenaseCrystal structure of formaldehyde dehydrogenase

Structural highlights

1kol is a 2 chain structure with sequence from Pseudomonas putida. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.65Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FADH_PSEPU Catalyzes the NAD(+)-dependent oxidation of formaldehyde and acetoaldehyde as well as long-chain alcohols but is inactive against propionaldehyde, butyraldehyde, methanol and ethanol. Can also catalyze the dismutation of a wide range of aldehydes such as formaldehyde.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Ogushi S, Ando M, Tsuru D. Formaldehyde dehydrogenase from Pseudomonas putida: a zinc metalloenzyme. J Biochem. 1984 Nov;96(5):1587-91. PMID:6526822
↑ Oppenheimer NJ, Henehan GT, Huete-Perez JA, Ito K. P. putida formaldehyde dehydrogenase. An alcohol dehydrogenase masquerading as an aldehyde dehydrogenase. Adv Exp Med Biol. 1997;414:417-23. PMID:9059646

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OCA

[1] Ogushi S, Ando M, Tsuru D. Formaldehyde dehydrogenase from Pseudomonas putida: a zinc metalloenzyme. J Biochem. 1984 Nov;96(5):1587-91. PMID:6526822

[2] Oppenheimer NJ, Henehan GT, Huete-Perez JA, Ito K. P. putida formaldehyde dehydrogenase. An alcohol dehydrogenase masquerading as an aldehyde dehydrogenase. Adv Exp Med Biol. 1997;414:417-23. PMID:9059646

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