1k12

Fucose Binding lectinFucose Binding lectin

Structural highlights

1k12 is a 1 chain structure with sequence from Anguilla anguilla. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FUCL_ANGAN Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Wu AM, Wu JH, Singh T, Liu JH, Herp A. Lectinochemical studies on the affinity of Anguilla anguilla agglutinin for mammalian glycotopes. Life Sci. 2004 Jul 16;75(9):1085-103. PMID:15207656 doi:http://dx.doi.org/10.1016/j.lfs.2004.02.016
↑ Bianchet MA, Odom EW, Vasta GR, Amzel LM. A novel fucose recognition fold involved in innate immunity. Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873 doi:10.1038/nsb817

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OCA

[1] Wu AM, Wu JH, Singh T, Liu JH, Herp A. Lectinochemical studies on the affinity of Anguilla anguilla agglutinin for mammalian glycotopes. Life Sci. 2004 Jul 16;75(9):1085-103. PMID:15207656 doi:http://dx.doi.org/10.1016/j.lfs.2004.02.016

[2] Bianchet MA, Odom EW, Vasta GR, Amzel LM. A novel fucose recognition fold involved in innate immunity. Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873 doi:10.1038/nsb817

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